Match4Life

Provide relevant genetic information for the best donor selection.

Match4Life

The analysis compares genetic variants found in carrier testing of two individuals to determine if they are genetically compatible.

Highlights

  • Provides a complete report that will help make decisions for better donor selection.
  • Compare the genetic variants found related to recessively inherited diseases.
  • Applicable to different levels of screening: treatable conditions, most common conditions, and all recessive conditions.

Match4Life

Match4Life is a pre-conceptional genetic test intended for matching between two patients to minimize the risk of getting an affected child.

To perform a Match4Life, both patients must first undergo a carrier test. By screening both patients, the test can ensure that disease-causing variants are not present in the same gene in each patient.

When are two persons genetically compatible?

In the Match4Life analysis, one person is Patient A and the other is Patient B.

Patient A’s carrier status is compared to patient B’s carrier status for the genes listed in the report. Both are compatible when they do not have variants that can transmit a disease in the same gene.

Transmission of a damaging variant one from Patient A and one from Patient B will cause the disease. If both are carriers of a variant in the same gene there is a 25% risk of having an affected child.

How to do the Match4Life?

  • To perform the Match4Life, a saliva or blood sample from both patients is necessary. The sample is used to perform a carrier test.
  • You can select from the following Amplexa carrier tests:
Genes2Life
Genes4Life
  • To collect the saliva sample, we will send a sample collection kit with instructions for collecting the sample, and shipping instructions for sending the sample to Amplexa Genetics.
  • You can expect a response no later than four weeks after we have received your sample.

Can perform Match4Life using a carrier test made by another genetic laboratory?

Amplexa Genetics performs Match4Life when:

  • Patient A and Patient B underwent carrier testing by Amplexa Genetics.
  • Patient A had carrier testing performed by Amplexa and patient B had carrier testing performed by another genetic laboratory. In this case, it is mandatory to deliver the result of the analysis carried out by the other laboratory.

The Analysis

Match4Life is a pre-conceptional genetic test intended for matching between two patients to minimize the risk of a getting an affected child. Patient B’s carrier status is then matched with carrier status of patient A in the genes listed in the report.

Match4Life reported variants

  • Class IV likely pathogenic
  • Class V pathogenic

All variants are evaluated based on current knowledge, and interpretation may change as new information becomes available.

Evaluation

Genetic variants are evaluated according to the ACMG guidelines. Based on the evaluation, variants are classified into five classes:

  • Class I: Benign
  • Class II: Likely benign
  • Class III: Uncertain significance
  • Class IV: Likely pathogenic
  • Class V: Pathogenic

Carrier screening testing options for compatibility with Match4Life

Match4Life can be used with our internal panels:

  • Genes2Life panel is based on the recommendations set by the American College of Obstetricians and Gynecologists.
  • Genes4Life panel includes both the Genes2Life and X-Linked Carrier test genes as well as many others.

Our panels are regularly updated according to the newest recommendations and knowledge obtained in the field of genetic diseases.

To learn more about how Match4Life can assist your donor selection program, please contact one of our experts for more information.

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