
Sperm donor screening is a fundamental genetic test for donors. The test analyzes genetic mutations in genes responsible for rare diseases with a recessive mode of inheritance.
Genes are selected according to the ethnic origin of the donor and the prevalence of rare diseases in the ethnic group; therefore, the number of genes analyzed may change. If a donor candidate has a mutation in one of the genes analyzed, the candidate cannot become a donor.
HEREDITARY DISEASES
Hereditary diseases are inherited through genetic material from one generation to another. In some cases, conditions can “skip” one generation and be inherited in the next; this happens in diseases with recessive inheritance. Recessive inheritance means that a person can carry disease-related mutations without being aware of them. Prevalence in medicine measures the total number of people in a specific group who have (or had) a particular disease,
condition, or risk factor at a particular point in time or during a given period.

Reference: https://www.medicinenet.com/prevalence/definition.htm
GENES ANALYZED AND THE PREVALENCE OF THE RELATED DISEASES:
Related diseases: Spinal muscular atrophy. Genes: SMN1.Statistics: 1 in 6000-10000 children are born with the disease. In the United Kingdom, approx. 2000-2500 children and adults with SMA.
Related diseases: Cystic fibrosis. Genes: CFTR.
Statistic: Approx. 1 in 30 people is a healthy carrier of cystic fibrosis without knowing it. In Denmark, 1-2 children are born with cystic fibrosis every month.
This represents approx. 150000 people in Denmark.
Related diseases: Non-syndromic genetic deafness. Genes: GJB2, GJB6 (DFNB1)
Statistic: 60-80% of cases of early-onset hearing loss are of genetic origin. Between 1 in 1000 were born with profound and 1 in 700 with severe hearing loss.
Related diseases: Tay- Sachs. Genes: HEXA.
Statistics: The prevalence of the diseases is 1 case per 320000 live births. 100 times more common among Ashkenazi Jews, with the number of carriers being around 1 per 30.
Reference: https://www.orpha.net/consor/cgi-bin/index.php?lng=EN
OUR RESULTS:
5 out of 100 sperm donor candidates analyzed by Amplexa Genetics were disqualified as donors.GET TESTED BEFORE:
- Selecting a sperm donor.
- Trying to get pregnant with a sperm donor.