I want to have a baby
SPERM DONOR SCREENING
Sperm donor screening is a fundamental genetic test for donors. The test analyzes genetic mutations in genes responsible for rare diseases with a recessive mode of inheritance. Genes are selected according to the ethnic origin of the donor and the prevalence of rare diseases in the ethnic group; therefore, the number of genes analyzed may change. If a donor candidate has a mutation in one of the genes analyzed, the candidate cannot become a donor.
Hereditary diseases are inherited through genetic material from one generation to another. In some cases, conditions can “skip” one generation and be inherited in the next; this happens in diseases with recessive inheritance. Recessive inheritance means that a person can carry disease-related mutations without being aware of them.
RECESSIVE GENETIC DISEASE
Two copies of the same mutated gene, one in the woman and one in the man, cause the disease.
Prevalence in medicine measures the total number of people in a specific group who have (or had) a particular disease, condition, or risk factor at a particular point in time or during a given period.
GENES ANALYZED AND THE PREVALENCE OF THE RELATED DISEASES:
Related diseases: Spinal muscular atrophy. Genes: SMN1. Statistics: 1 in 6000-10000 children are born with the disease. In the United Kingdom, approx. 2000-2500 children and adults with SMA. Related diseases: Cystic fibrosis. Genes: CFTR. Statistic: Approx. 1 in 30 people is a healthy carrier of cystic fibrosis without knowing it. In Denmark, 1-2 children are born with cystic fibrosis every month. This represents approx. 150000 people in Denmark. Related diseases: Non-syndromic genetic deafness. Genes: GJB2, GJB6 (DFNB1) Statistic: 60-80% of cases of early-onset hearing loss are of genetic origin. Between 1 in 1000 were born with profound and 1 in 700 with severe hearing loss. Related diseases: Tay- Sachs. Genes: HEXA. Statistics: The prevalence of the diseases is 1 case per 320000 live births. 100 times more common among Ashkenazi Jews, with the number of carriers being around 1 per 30.
5 out of 100 sperm donor candidates analyzed by Amplexa Genetics were disqualified as donors.
GET TESTED BEFORE:
- Selecting a sperm donor.
- Trying to get pregnant with a sperm donor.