BIOINFORMATICS

Bioinformatics is an interdisciplinary field that works with processing raw data into useful information so that clinicians and researchers can utilize the combined knowledge in the specific field. Bioinformatics is about taking the new data and combining it with databases and, via statistics, designating important parts that can be used to draw conclusions within diagnostics and research.

At Amplexa Genetics, we have a department of trained bioinformatics employees with a broad experience in both human genetics and microbiology. We can help you with everything from experimental design, the actual sequencing, data analysis, interpretation, as well as the production of publishable figures for the script or presentation. We have experience with many different data types, including NGS data from Illumina platforms, Ion Torrent platforms, as well as NanoPore, and Sanger. In addition, we have experience with a large number of types of analysis, including:

  • Single Nucleotide Polymorphism (SNP) and variant calling on both human and microbial genomes.
  • Chromosome copynumber variation (CNV) calling on human genomes.
  • Comparative genomics, ie. comparison of genomes at both a macroscopic level where 1000 <genomes are compared, but also within e.g. Trio analyzes in which familial genomes are examined to diagnose epileptic phenotypes.
  • De novo assembly of a number of organisms, including the silverfish, herring and a number of bacteria.
  • Pan genomics where a large number of genomes are compared to find genes related to traits, such as discharge of virulence factors by a group of bacteria or during antibiotic resistance.
  • Transcriptomics where the expression of genes is examined and compared between cell lines and / or organisms. Of course, this also includes the ability to look for regulatory RNAs.
  • DNA modifications where the DNA itself is examined for specific modifications such as methylations and acetylations.

Our bioinformatics staff is always open to new challenges, so contact us for a free project discussion, even if you have a project that is not reminiscent of any of the above.